![simpliderm_logo-min SimpliDerm logo](https://sientra.com/wp-content/uploads/2023/08/simpliderm_logo-min.png)
![simpliderm_logo-min SimpliDerm logo](https://sientra.com/wp-content/uploads/2023/08/simpliderm_logo-min.png)
Better process,better results.1
SimpliDerm’s proprietary, patented and gentle process achieves a sterility assurance level (SAL) of 10-6 with minimal impact to the extracellular matrix and key growth factors. This innovative process results in better handling and performance, healthy inflammatory response and rapid tissue integration.1, 2
Designed for Consistency
Designed to meet the needs of board-certified plastic surgeons, the SimpliDerm process prioritizes consistency in thickness within and between pieces for optimal results.
![simpliderm_diagram_desktop-min SimpliDerm diagram](https://sientra.com/wp-content/uploads/2023/08/simpliderm_diagram_desktop-min.jpg)
![simpliderm_diagram_mobile-min SimpliDerm diagram](https://sientra.com/wp-content/uploads/2023/08/simpliderm_diagram_mobile-min.jpg)
Greater tissue strength2
![simpliderm_suture_retention_strength_chart_baseline-min Chart depicting SimpliDerm Suture Retention Strength - Baseline](https://sientra.com/wp-content/uploads/2023/08/simpliderm_suture_retention_strength_chart_baseline-min.jpg)
![simpliderm_suture_retention_strength_chart_12_weeks-min Chart depicting SimpliDerm Suture Retention Strength - 12 weeks after implantation](https://sientra.com/wp-content/uploads/2023/08/simpliderm_suture_retention_strength_chart_12_weeks-min.jpg)
SeeBetter Handling and Performance2
SimpliDerm’s structural composition is similar to native dermis and exhibits greater strength than other hADMs, while maintaining pliability.2
SeeHealthy inflammatory response1
SimpliDerm demonstrated reduced inflammatory and fibrotic responses when compared to AlloDerm™ RTU in a non-human primate model.1
![simpliderm_inflammatory_response_chart-min Chart depicting Pro-inlammatory M1 Macrophage protein (TNFa) levels over 12 weeks for SimpliDerm and AlloDerm RTU](https://sientra.com/wp-content/uploads/2023/08/simpliderm_inflammatory_response_chart-min.jpg)
SimpliDerm demonstrated reduced inflammatory response compared to AlloDerm™ RTU at 4 weeks1
![simpliderm_cd68_staining-min SimpliDerm CD68 Staining image](https://sientra.com/wp-content/uploads/2023/08/simpliderm_cd68_staining-min.jpg)
![alloderm_cd68_staining-min AlloDerm CD68 Staining image](https://sientra.com/wp-content/uploads/2023/08/alloderm_cd68_staining-min.jpg)
CD68: marker indicative of inflammation
Preserved vascular channels (baseline)2
![simpliderm_type_iv_collagen-min Preserved vascular channels (baseline)](https://sientra.com/wp-content/uploads/2023/08/simpliderm_type_iv_collagen-min.jpg)
Robust tissue generation at 12 weeks2
![simpliderm_massons_trichrome-min Robust tissue generation at 12 weeks](https://sientra.com/wp-content/uploads/2023/08/simpliderm_massons_trichrome-min.jpg)
SeeRapid Tissue Integration1
SimpliDerm’s innovative process results in minimal impact to the extracellular matrix, which allows for a healthy regenerative response and rapid tissue integration.1,2
By preserving the extracellular matrix, including vascular channels, SimpliDerm facilitates angiogenesis, resulting in new collagen formation, revascularization and host cell repopulation.1,2
By preserving the extracellular matrix, including vascular channels, SimpliDerm facilitates angiogenesis, resulting in new collagen formation, revascularization and host cell repopulation.1,2